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ProteinFind® Anti-CD63 Mouse Monoclonal Antibody

目录号: HE904-01

单 价:¥600

规格:
20 µl
数量:
-
+
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产品详情介绍

CD63是一种广泛表达的蛋白,定位于核内体系统和细胞表面,又称为血小板糖蛋白40(platelet glycoprotein 40, Pltgp40)或黑色素瘤抗原491(ME491)等,主要存在于晚期核内体/多囊泡(MVBs)和溶酶体中[1]。CD63与囊泡运输活动相关,与多种肿瘤的发生、转移存在一定的联系。在卵巢癌中,低表达水平的CD63与肿瘤转移相关[2];在肺腺癌中,低表达CD63与肿瘤转移及预后差相关[3];在乳腺癌和结肠癌中,CD63表达与肿瘤侵袭和转移呈负相关[4,5]。本产品为小鼠抗人CD63单克隆抗体,用于WB、IF和FC方法特异性检测人CD63蛋白。


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References

[1] Pols MS, Klumperman J. Trafficking and function of the tetraspanin CD63 [J]. Exp Cell Res. 2009, 315(9): 1584-92.

[2] Zhijun X, Shulan Z, Zhuo Z. Expression and significance of the protein and mRNA of metastasis suppressor gene ME491/CD63 and integrin alpha5 in ovarian cancer tissues [J]. Eur J Gynaecol Oncol. 2007, 28(3): 179-83.

[3] Kwon MS, Shin SH, Yim SH, et al. CD63 as a biomarker for predicting the clinical outcomes in adenocarcinoma of lung [J]. Lung Cancer. 2007, 57(1): 46-53.

[4] Sauer G, Kurzeder C, Grundmann R, et al. Expression of tetraspanin adaptor proteins below defined threshold values is associated with in vitro invasiveness of mammary carcinoma cells [J]. Oncol Rep. 2003, 10(2): 405-10. 

[5] Sordat I, Decraene C, Silvestre T, et al. Complementary DNA arrays identify CD63 tetraspanin and alpha3 integrin chain as differentially expressed in low and high metastatic human colon carcinoma cells [J]. Lab Invest. 2002, 82(12): 1715-24.


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